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Applications of magnetic stirrers in pharmaceutical equipment
Release time：
2025-04-14
As one of the commonly used power devices, magnetic stirrers are widely used in the chemical, food, dye, cosmetics, and pharmaceutical industries. Magnetic stirrers have become a popular trend in the biopharmaceutical industry. Let's learn about the application of magnetic stirrers in pharmaceutical equipment!
Magnetic stirrers, as one of the commonly used power devices, are widely used in the chemical, food, dye, cosmetics, and pharmaceutical industries. Magnetic stirrers have become a popular trend in the biopharmaceutical industry. Let's learn about the application of magnetic stirrers in pharmaceutical equipment!
A magnetic stirrer is a device that forces convection and uniform mixing of liquid and gaseous media. Various mixers have been used since before the Industrial Revolution. After the Industrial Revolution, the applications of stirrers have become increasingly diverse and specialized. Today's applications and knowledge of stirrers are accumulated and improved based on traditional production and life practices.
The type, size, and speed of a magnetic stirrer affect the power distribution between overall flow and turbulent pulsation. Generally, the power distribution of a turbine mixer is conducive to turbulent pulsation, while the paddle mixer is conducive to overall flow. For the same type of stirrer under the same power consumption, a large-diameter, low-speed stirrer mainly consumes power in the entire process, which is conducive to macroscopic mixing. A small-diameter, high-speed stirrer mainly consumes power on turbulent pulsation, which is conducive to microscopic mixing.
Biopharmaceutical manufacturing places higher demands on the sterility and risk control of mixer shaft seals.
The working principle of a magnetic stirrer is to utilize the characteristic of repulsion between magnetic substances of the same polarity. By continuously changing the polarity at both ends of the base to rotate the magnetic stirring bar. The disadvantage is that the energy conversion efficiency is low, and it is only suitable for stirring small volumes of liquid.
On the other hand, the working principle of a magnetic stirrer is that there is a partition between the inner and outer magnets. When the motor is driven, the inner and outer magnets are magnetically coupled to achieve transmission. It is widely used in pumps, and magnetic pumps are completely leak-proof and have high energy conversion efficiency. The counterpart to the bottom magnetic stirrer is the top magnetic stirrer, but because it does not completely eliminate the risks associated with shaft seals, its application is limited.
Because stirring is an experimental science, the scaling up of magnetic stirrers is a complex process-related problem. To date, it can only be scaled up through gradual experience and extrapolated to industrial scale based on the obtained scaling-up basis. Currently, the scaling up of magnetic stirrers mainly relies on simulation tests by manufacturers using ordinary buffer solutions as the main model solutions. The standardization and scaling up are based on this, and all customized types are improvements based on the standard model, such as material customization, power customization, and paddle shape customization. The correct selection of a suitable mixer is a problem that users need to solve. Application of magnetic stirrers
Magnetic stirrers and magnetic stirring bars have been widely used, but only in R&D and small-scale applications. The demand for stronger force, higher power, larger volume, elimination of dead zones, and online cleaning (CIP) and online sterilization (SIP) of magnetic stirrers currently exists. Bottom magnetic stirrers are suitable for stirring 40 tons of water or even more, and have a wide range of applications. Structurally, a typical bottom magnetic stirrer consists of a rotating head with a mother bearing; it is composed of a male bearing, a tank bottom welding plate, and a motor. The motor-driven head has several permanent magnets (non-annular), and the rotating head has the same number of permanent magnets at the corresponding positions, with closely matched polarities. After installation, the permanent magnets of the motor-driven head and the rotating head are magnetically coupled. The motor-driven head rotates, and the rotating head rotates under the action of magnetic force. The two are completely separated by the tank bottom plate, and the mechanical transmission shaft does not penetrate the tank.
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